Mancherial District is carved out of erstwhile Adilabad District. It is surrounded by Asifabad (Komuram Bheem), Adilabad, Nirmal, Jagtial, Peddapalli, Bhoopalapally districts and the Maharashtra state.

The district comprises of 18 mandals and Two Revenue Divisions – Mancherial and Bellampalli. The district headquarters is located at Mancherial town.

Mancherial is well connected through its roadways and railways. Mancherial is one of the A category stations of Secunderabad division and Bellampalli is also a major railway station in the region. The SH1, NH63 and Nagpur highway, run through the district, making the entire region well linked. It has one RTC depot at Mancherial.

Rivers Godavari and Pranahita pass through it. Paddy is the major crop in the district.

Housing a precious coal belt, the district is home to Singareni Collieries and Jaipur Thermal Power Plant. It also possesses several private cement manufacturers and ceramics factories. And the ceramic pipe industry, which is the largest in the in the country, is definitely an icing on the cake.

Mancherial district boasts of the crocodile sanctuary near Chennur and thick forest under a part of the Kawal Tiger Reserve. Gudemgutta Sri Satyanarayana Swami Temple is a noted pilgrim centre in the district.